Trifluoroacetic Acid
Trifluoroacetic acid is a corrosive organofluorine compound that is structurally analogous to, but stronger than, acetic acid. Available in various quantities and reagent grades, it is used in NMR spectroscopy, mass spectrometry, organic synthesis, etc.
Almost 100,000-fold more acidic than acetic acid, TFA is widely used in organic chemistry. TFA is used as a reagent in organic synthesis because of its properties: volatility, organic solvent solubility, and acidic strength. It is less oxidizing than sulfuric acid and is more readily available in its anhydrous form than some other acids . Other features include:
- Used in acid-catalyzed reactions, especially peptide synthesis (to cleave esters)
- Dissolves protein when mixed with liquid SO2
- Removes t-butyl derived side-chain protecting groups in Fmoc peptide synthesis
- Can remove the t-butoxycarbonyl protecting group in organic synthesis
- At low concentrations, acts as an ion-pairing agent for peptides and small proteins in organic compound liquid chromatography
- For acid-stable materials, can be a solvent for NMR spectroscopy
- Acts as a calibrant in mass spectrometry
- Used to produce trifluoroacetate salts
- An ingredient in adhesives, sealants, paints, and coatings
When TFA combines with bases and metals, especially light metals, a strong exothermic reaction occurs. When mixed with lithium aluminum hydride (LAH), the reaction is explosive.
Although nonflammable, TFA is corrosive to skin, eyes, and mucous membranes and requires careful use and handling. It is harmful when inhaled, causes severe skin burns and eye damage, and is toxic to aquatic organisms at even low concentrations.
TFA is also a product of the metabolic breakdown of the anesthetic agent halothane. It is the suspected cause of halothane-induced hepatitis.
Medchemexpress LLC MTvkPABC-P5 TFA | 98.8% | 1190.22 Da | C54H74F3N11O16 | 1 MG
MTvkPABC-P5 TFA is the trifluoroacetic acid (TFA) salt form of a Toll-like receptor 7 (TLR7) agonist used as an immune stimulant and as a synthetic building block for immune-stimulating antibody conjugates (ISACs).
- Acts as a Toll-like receptor 7 (TLR7) agonist and immune stimulant.
- Used as a building block for synthesis of immune-stimulating antibody conjugates (ISACs).
- Provided as a TFA salt for improved handling and stability.
- Reported high purity suitable for research use.
- Offered in small mg pack sizes for laboratory applications.
Medchemexpress LLC UNC0379 trifluoroacetate | 1620401-83-3 | MFCD28167817 | 99.9% | 527.58 g·mol⁻¹ | C25H36F3N5O4 | 5MG
UNC0379 trifluoroacetate is the trifluoroacetate salt of UNC0379, a selective substrate-competitive inhibitor of the lysine methyltransferase SETD8 (KMT5A). It is supplied as a high-purity research reagent for biochemical and cellular studies, with reported activity IC50 = 7.3 μM and KD = 18.3 μM. For laboratory research use only.
Medchemexpress LLC BIM 23042 (trifluoroacetate) | 00-00-0 | MFCD32666112 | 96.2% | 1192.45 g/mol | C63H73N11O9S2·xC2HF3O2 | 1 MG
BIM 23042 (trifluoroacetate) is a somatostatin-like octapeptide analogue that acts as a selective neuromedin B receptor (NMB-R/BB1) antagonist. It is supplied as the trifluoroacetate salt in solid form for research use in receptor pharmacology and intracellular calcium signaling studies.
- Selective neuromedin B receptor (NMB-R/BB1) antagonist.
- Somatostatin-like octapeptide structure as the trifluoroacetate salt.
- Purity approximately 96.2% by supplier analysis.
- White to off-white solid powder suitable for laboratory use.
- Store sealed away from moisture and light; powder stable at -80°C (2 years) or -20°C (1 year).
Medchemexpress LLC Alvespimycin (17-DMAG) trifluoroacetate | 00-00-0 | MFCD08457919 | 99.0% | 730.77 g/mol | C34H49F3N4O10 | 5 MG
Alvespimycin TFA is the trifluoroacetate salt of 17-DMAG, a small-molecule inhibitor of heat shock protein 90 (Hsp90) used as a research reagent to study Hsp90-dependent signaling and anticancer mechanisms. The compound binds Hsp90 with an EC50 of 62 nM and is supplied as a high-purity, pale purple solid for laboratory use.
- Potent Hsp90 inhibitor (EC50 62 nM).
- Trifluoroacetate (TFA) salt form for consistent handling.
- High purity (reported ~98.97%).
- Molecular weight 730.77 g/mol.
- Pale purple solid appearance.
- Storage: sealed, away from moisture and light; in solvent, -80°C (6 months) or -20°C (1 month).
Medchemexpress LLC Lys-CoA TFA (Lys-coenzyme A) | 98.5% | 1 MG
Lys-CoA TFA is a selective p300 histone acetyltransferase (HAT) inhibitor with an IC50 of 50-500 nM. It demonstrates over 100-fold selectivity for p300 compared to PCAF (IC50=200 μM). This compound works by inhibiting p300 HAT activity-dependent transcriptional activation.
- Selective p300 histone acetyltransferase (HAT) inhibitor
- IC50 of 50-500 nM for p300
- Over 100-fold selectivity for p300 compared to PCAF
- Induces a senescent phenotype in human normal melanocytes at 0.1 and 1 mM concentrations
- Inhibits cyclin E expression in a dose-dependent manner
Medchemexpress LLC Lys-CoA TFA | 98.5% | 50 MG
Lys-CoA TFA is a selective p300 histone acetyltransferase (HAT) inhibitor with an IC50 of 50-500 nM. It demonstrates over 100-fold selectivity for p300 compared to PCAF (IC50=200 μM). Lys-CoA TFA effectively inhibits p300 HAT activity-dependent transcriptional activation.
- Selective p300 histone acetyltransferase (HAT) inhibitor
- Displays >100-fold selectivity for p300 over PCAF
- Inhibits p300 HAT activity-dependent transcriptional activation
- Induces a senescent phenotype in human normal melanocytes at concentrations of 0.1 and 1 mM over 60 hours
- Almost completely abolished proliferation, induced high levels of SA-β-Gal, and inhibited cyclin E expression in a dose-dependent manner in normal human melanocytes
- For research use only
Medchemexpress LLC Tmprss6-in-1 Tfa | 1 MG
Tmprss6-in-1 TFA is a potent inhibitor of Tmprss6 (Matriptase-2), a type II transmembrane serine protease (TTSP). Genetic reduction of Tmprss6 has shown to improve symptoms of hemochromatosis and beta thalassemia in mice.
- Potent inhibitor of Tmprss6 (Matriptase-2)
- Belongs to transmembrane serine proteases (TTSPs)
- Molecular weight: 790.88
- Formula: C35H41F3N8O6S2
- Appearance: Solid
- Soluble in Dmso at 125 mg/mL (158.05 mM)
- Target: Ser/Thr protease
- Pathway: Metabolic enzyme/protease
- For research use only
Medchemexpress LLC MC-VC-PAB-NH2 trifluoroacetic acid | 1616727-21-9 | 99.9% | C33H47F3N8O10 | 10MG
MC-VC-PAB-NH2 TFA is a cleavable ADC linker supplied as the trifluoroacetic acid salt for research use. It contains a Val-Cit-PAB cleavable spacer designed for protease-triggered drug release and is provided as a white to off-white solid with high purity.
- Provides a protease-cleavable Val-Cit-PAB spacer for controlled payload release.
- Supplied as a TFA salt to aid handling and stability.
- High purity (≈99.9%) suitable for conjugation workflows.
- Soluble in DMSO at high concentration (100 mg/mL) with ultrasonic assistance.
- Solid, white to off-white appearance for convenient storage and handling.
- Storage recommendations: sealed, away from moisture and light; in solvent: -80°C (6 months), -20°C (1 month).
- Intended for research use only; not for human or clinical use.
Medchemexpress LLC Bibo3304 | 191868-14-1 | 100.0% | 643.66 | C31H36F3N7O5 | 25 MG
BIBO3304 is a potent, selective neuropeptide Y (NPY) Y1 receptor antagonist used as a research probe. It exhibits subnanomolar affinity at human and rat Y1 receptors (IC50 = 0.38 nM and 0.72 nM) and is supplied in solid and solution formats with high reported purity.
- High potency with subnanomolar IC50 values for human and rat Y1 receptors.
- High reported purity (99.96%).
- Available as solid and as a 10 mM DMSO solution for assay readiness.
- Molecular formula C31H36F3N7O5 and molecular weight 643.66 g/mol.
- Suitable for receptor pharmacology and in vitro pharmacodynamic studies.
Medchemexpress LLC MIP-1095 trifluoroacetate | 00-00-0 | MFCD09802015 | 99.8% | 678.35 g/mol | C21H26F3IN4O10 | 5 MG
MIP-1095 trifluoroacetate is a small-molecule inhibitor of prostate-specific membrane antigen used for research and imaging probe development. The compound is supplied as a high-purity trifluoroacetate salt, suitable for radiolabeling and preclinical assays.
- Potent inhibitor of prostate-specific membrane antigen (PSMA).
- Provided as trifluoroacetate (TFA) salt for stability.
- High purity suitable for research applications.
- Compatible with radiolabeling for imaging probe development.
- Soluble in DMSO for assay preparation.
- Available in small-mass quantities for preclinical studies.
Medchemexpress LLC Batifiban TFA | 00-00-0 | 99.6% | 817.94 g/mol | C34H47N11O9S2 · xC2HF3O2 | 5 MG
Batifiban TFA is a cyclic peptide antagonist of platelet glycoprotein IIb/IIIa that inhibits platelet aggregation by blocking ligand binding such as vitronectin. Supplied as the trifluoroacetate (TFA) salt for research use, it is provided as a high-purity powder suitable for in vitro biochemical and cellular assays.
- Antagonizes platelet glycoprotein IIb/IIIa to inhibit aggregation.
- Blocks vitronectin binding to integrin receptors.
- Supplied as trifluoroacetate (TFA) salt for stability.
- High purity (~99.6%) suitable for biochemical assays.
- Available in small research pack sizes, including 5 mg.
- Store sealed, away from moisture and light; long-term storage at -80°C.
Medchemexpress LLC Galnon TFA | 1217448-19-5 | MFCD06798339 | 98.9% | 792.84 | C42H47F3N4O8 | 5 MG
Galnon TFA is a selective, non-peptide agonist of galanin receptors GAL1 and GAL2 used in neuroscience research. It binds GAL1 and GAL2 with reported Kis of 11.7 μM and 34.1 μM and has demonstrated anticonvulsant and anxiolytic effects. The compound is supplied as a white to off-white solid with high purity and is soluble in DMSO for in vitro use.
- Selective galanin receptor agonist (GAL1 and GAL2).
- Demonstrated anticonvulsant and anxiolytic activity in preclinical models.
- High purity (98.9%) and white to off-white solid appearance.
- Soluble in DMSO (125 mg/mL); use fresh DMSO and ultrasonic assistance if needed.
- Recommended storage sealed, protected from moisture and light; frozen solution stability varies by temperature.
Medchemexpress LLC N-acetyl-L-valyl-L-alpha-glutamyl-L-isoleucyl-L-aspart-1-al | 00-00-0 | MFCD01318861 | 99.8% | 614.57 g/mol | C24H37F3N4O11 | 5 MG
Ac-VEID-CHO TFA is a peptide-derived aldehyde inhibitor of caspases used in biochemical research to study apoptosis and neurodegenerative disease mechanisms. The trifluoroacetate salt is supplied as a white to off-white solid with high purity and is suitable for assays requiring nanomolar potency against executioner caspases.
- Purity 99.8% by HPLC.
- Potent inhibition of caspase-3, caspase-6, and caspase-7 (IC50: 13.6 nM, 16.2 nM, 162.1 nM).
- Supplied as a solid, white to off-white powder.
- Soluble in water at approximately 1 mg/mL with sonication and warming.
- Storage recommendations include cold, sealed conditions to preserve stability.
- Designed for research applications in apoptosis and neurodegenerative disease models.
- Available in small research-scale quantities for assay development.
Medchemexpress LLC OS-2966 10mg | 10mg
OS-2966 is a humanized antibody expressed in CHO cells targeting Integrin b1/ITGB1/CD29 OS-2966 carries a huIgG1 type heavy chain and a hu type light chain with a predicted molecular weight (MW) of 145 5 kDa The isotype control for OS-2966 can be referenced as Human IgG1 kappa Isotype Control (HY-P99001)
Medchemexpress LLC OS-2966 5mg | 5mg
OS-2966 is a humanized antibody expressed in CHO cells targeting Integrin b1/ITGB1/CD29 OS-2966 carries a huIgG1 type heavy chain and a hu type light chain with a predicted molecular weight (MW) of 145 5 kDa The isotype control for OS-2966 can be referenced as Human IgG1 kappa Isotype Control (HY-P99001)