Trifluoroacetic Acid
Trifluoroacetic acid is a corrosive organofluorine compound that is structurally analogous to, but stronger than, acetic acid. Available in various quantities and reagent grades, it is used in NMR spectroscopy, mass spectrometry, organic synthesis, etc.
Almost 100,000-fold more acidic than acetic acid, TFA is widely used in organic chemistry. TFA is used as a reagent in organic synthesis because of its properties: volatility, organic solvent solubility, and acidic strength. It is less oxidizing than sulfuric acid and is more readily available in its anhydrous form than some other acids . Other features include:
- Used in acid-catalyzed reactions, especially peptide synthesis (to cleave esters)
- Dissolves protein when mixed with liquid SO2
- Removes t-butyl derived side-chain protecting groups in Fmoc peptide synthesis
- Can remove the t-butoxycarbonyl protecting group in organic synthesis
- At low concentrations, acts as an ion-pairing agent for peptides and small proteins in organic compound liquid chromatography
- For acid-stable materials, can be a solvent for NMR spectroscopy
- Acts as a calibrant in mass spectrometry
- Used to produce trifluoroacetate salts
- An ingredient in adhesives, sealants, paints, and coatings
When TFA combines with bases and metals, especially light metals, a strong exothermic reaction occurs. When mixed with lithium aluminum hydride (LAH), the reaction is explosive.
Although nonflammable, TFA is corrosive to skin, eyes, and mucous membranes and requires careful use and handling. It is harmful when inhaled, causes severe skin burns and eye damage, and is toxic to aquatic organisms at even low concentrations.
TFA is also a product of the metabolic breakdown of the anesthetic agent halothane. It is the suspected cause of halothane-induced hepatitis.
Medchemexpress LLC 2-Furancarboxamide, 5-nitro-N-[4-[7-(1,2,3,6-tetrahydro-4-pyridinyl)imidazo[1,2-a]pyridin-3-yl]phenyl] | C25H20F3N5O6 | 5 MG
W1131 TFA is a potent STAT3 inhibitor that induces ferroptosis. It inhibits cancer progression in subcutaneous xenograft, organoid, and PDX models of gastric cancer. W1131 effectively alleviates cancer cell chemoresistance to 5-FU, and regulates the cell cycle, DNA damage response, and oxidative phosphorylation, including the IL6-JAK-STAT3 pathway and the ferroptosis pathway.
- Potent STAT3 inhibitor
- Induces ferroptosis
- Inhibits cancer progression in gastric cancer models
- Alleviates cancer cell chemoresistance to 5-FU
- Regulates cell cycle and DNA damage response
- Regulates oxidative phosphorylation
- Regulates IL6-JAK-STAT3 pathway
- Regulates ferroptosis pathway
Medchemexpress LLC RC-3095 TFA | 1217463-61-0 | 1220.34 | 1 MG
RC-3095 TFA | 1217463-61-0 | 1220.34 | 1 MG
Medchemexpress LLC GRL-1720 TFA | 2835511-03-8 | C16H12ClF3N2O4 | 5 MG
GRL-1720 TFA is a potent inhibitor of SARS-CoV-2 Mpro, exhibiting anti-SARS-CoV2 activity with an EC50 value of 15 μM. This compound has a molecular weight of 388.73 and appears as a solid, ranging from light brown to brown in color.
- High purity of 98.94%.
- Shipped at room temperature.
- Store at -20°C, sealed, away from moisture.
- In solution, stable for 6 months at -80°C or 1 month at -20°C with sealed storage, away from moisture.
Medchemexpress LLC Tfllr-nh2(tfa) | 1313730-19-6 | 99.6% | 761.83 | 5 MG
TFLLR-NH2 (TFA) is a selective PAR1 agonist with an EC50 of 1.9 μM, intended for research use only. It appears as a white to off-white solid.
- Acts as a selective PAR1 agonist
- Stimulates concentration-dependent increases in [Ca2+]i in neurons
- Activated platelets upregulate E-cadherin and downregulate vimentin expression in SW620 cells
- Increases secreted TGF-β1 in platelet cultures
- Injection into rat paws stimulates marked and sustained oedema
- Stimulates Evans blue extravasation in various organs in wild-type mice
- Can induce both contraction and relaxation in rat duodenal smooth muscle
- Recommended storage for powder is -80°C for 2 years or -20°C for 1 year
- Recommended storage in solvent is -80°C for 6 months or -20°C for 1 month
- High solubility in DMSO and H2O (100 mg/mL)
Medchemexpress LLC TD-0212 TFA 10mM | 10MM 1ML
TD-0212 TFA is an orally active dual pharmacology angiotensin II type 1 receptor (AT1) antagonist and neprilysin (NEP) inhibitor with a pKi of 8 9 for AT1 and a pIC50 of 9 2 for NEP[1]
Medchemexpress LLC PSMA I&S TFA | 98.2% | 1413.43 | 1 MG
PSMA I&S (TFA) is a precursor of the 99mTc-labeled PSMA-targeting ligand, appearing as a white to off-white solid.
- Target PSMA
- Inhibits immunology/inflammation pathway
- Soluble in DMSO (100 mg/mL)
- Soluble in various in vivo dissolution methods
- Store at -20°C, protected from light and under nitrogen
Medchemexpress LLC TP0628103 (TFA) | 2865106-78-9 | 99.6% | 1248.68 | 5 MG
TP0628103 (Compound 18) TFA is a selective inhibitor of MMP-7, with an IC50 value of 0.17 nM. MMP-7 plays an important role in cancer and fibrosis.
- Selective inhibitor of MMP-7
- IC50 value of 0.17 nM
- Plays an important role in cancer and fibrosis research
- For research use only
Medchemexpress LLC LL-37 amide TFA | 99.3% | 4492.28 | 10 MG
LL-37 amide TFA is a selective agonist of formyl peptide receptor-like FPRL1, effective in inhibiting periodontal pathogens. It functions by activating FPRL1-mediated immune cell chemotaxis and disrupting bacterial cell membrane integrity. This modified form of LL-37 also regulates inflammatory responses, promotes angiogenesis, and shows improved stability and enhanced resistance to enzymatic degradation compared to natural LL-37.
- Effective against periodontal pathogens
- Activates FPRL1-mediated immune cell chemotaxis
- Disrupts bacterial cell membrane integrity
- Regulates inflammatory responses and promotes angiogenesis
- Improved stability and resistance to enzymatic degradation
- Good antibacterial effects against Gram-positive and Gram-negative bacteria
- Used in research for infection-related diseases and wound healing
Medchemexpress LLC Ampreloxetine trifluoroacetate | 1227056-85-0 | 98.3% | 5 MG
Ampreloxetine trifluoroacetate (TFA) is the trifluoroacetate salt of ampreloxetine, an orally active norepinephrine and serotonin (5-HT) uptake inhibitor investigated for research into neurogenic orthostatic hypotension. Supplied as a white to off-white solid with high purity for laboratory research use only.
- High purity (98.3%) suitable for research applications.
- Trifluoroacetate salt form to improve stability and solubility properties.
- Molecular weight 435.36 g/mol; formula C20H19F6NO3.
- Available in small research pack sizes (e.g., 5 MG) for assay development and preclinical studies.
- Intended for laboratory research use only; not for human or animal therapeutic use.
Medchemexpress LLC Gsnkskpk-nh2 (TFA) | 99.9% | 843.97 (free base) | 5 MG
GSNKSKPK-NH2 TFA is a model peptide based on a c-Src N-terminal peptide, which serves as an NMT substrate.
- Purity: 99.9%
- Appearance: White to off-white solid
- Sequence: Gly-Ser-Asn-Lys-Ser-Lys-Pro-Lys-NH2
- Molecular formula: C35H65N13O11.xC2HF3O2
- Soluble in water and DMSO
Medchemexpress LLC Lonodelestat TFA | 906547-89-5 | 99.6% | 1478.73 | 25 MG
Lonodelestat (POL6014) is a potent, orally active, and selective peptide inhibitor of human neutrophil elastase (hNE). It has potential for research related to cystic fibrosis (CF).
- Potent, orally active, and selective peptide inhibitor of human neutrophil elastase.
- Significantly reduced inflammatory processes of acute lung injury in HNE-treated mice.
- Suitable for research related to cystic fibrosis.
- Soluble in H2O: 20 mg/mL (13.53 mM); requires ultrasonic and warming.
- Powder storage: -80°C for 2 years, -20°C for 1 year.
- In solvent storage: -80°C for 6 months, -20°C for 1 month (sealed storage, away from moisture).